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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 61312
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDStreptozocin results in increased activity of TIMP2 protein

PMID:25246140
increases expressionEXP 6480464CTDStreptozocin results in increased expression of TIMP2 mRNA, Streptozocin results in increased expression of TIMP2 protein

PMID:16732983, PMID:20821936
multiple interactionsEXP 6480464CTDbenazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA], benazepril inhibits the reaction [Streptozocin results in increased expression of TIMP2 protein], Olive Oil promotes the reaction [Streptozocin results in increased activity of TIMP2 protein]

PMID:16732983, PMID:20821936, PMID:25246140
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.