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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737494
Species: Homo sapiens
CRRD Object: Gene
Symbol: SYP
Name: synaptophysin
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:113736480464CTDStreptozocin results in decreased expression of SYP protein

PMID:28499986
decreases expressionISORGD:38026480464CTDStreptozocin results in decreased expression of SYP mRNA, Streptozocin results in decreased expression of SYP protein

PMID:22062134
increases expressionISORGD:113736480464CTDStreptozocin results in increased expression of SYP mRNA

PMID:18487452
multiple interactionsISORGD:113736480464CTDAcetylcysteine inhibits the reaction [Streptozocin results in decreased expression of SYP protein], Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SYP protein], telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein], Valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]

PMID:18487452, PMID:28499986
multiple interactionsISORGD:38026480464CTDfasudil inhibits the reaction [Streptozocin results in decreased expression of SYP mRNA], fasudil inhibits the reaction [Streptozocin results in decreased expression of SYP protein]

PMID:22062134
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.