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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620980
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Tek
Name: TEK receptor tyrosine kinase
Acc ID: CHEBI:9352
Term: sulindac
Definition: A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
Chemical ID: MESH:D013467
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISOCRRD:15524646480464CTDSulindac analog results in decreased phosphorylation of and results in decreased activity of TEK protein

PMID:16215210
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.