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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737494
Species: Homo sapiens
CRRD Object: Gene
Symbol: SYP
Name: synaptophysin
Acc ID: CHEBI:9434
Term: telmisartan
Definition: A member of the class of benzimidazoles used widely in the treatment of hypertension.
Chemical ID: MESH:C084178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:113736480464CTDtelmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]

PMID:18487452
multiple interactionsISORGD:38026480464CTDtelmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein], telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]

PMID:18487452
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.