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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 736749
Species: Homo sapiens
CRRD Object: Gene
Symbol: SSR4
Name: signal sequence receptor subunit 4
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDThapsigargin results in increased expression of SSR4 mRNA

PMID:22378314, PMID:29453283
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.