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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 620575
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:9747
Term: Triptolide
Definition: An oxacycle that has formula C20H24O6.
Chemical ID: MESH:C001899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDtriptolide results in increased expression of APAF1 protein

PMID:25169008
multiple interactionsEXP 6480464CTDNFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein]

PMID:25169008
increases expressionISORGD:7332946480464CTDtriptolide results in increased expression of APAF1 protein

PMID:25169008, PMID:26990902
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.