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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 730973
Species: Mus musculus
CRRD Object: Gene
Symbol: Srebf2
Name: sterol regulatory element binding factor 2
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7309726480464CTD[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased abundance of Cholesterol, [[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased expression of HMGCR mRNA, [[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein] which results in decreased expression of LDLR mRNA, [troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 mRNA, [troglitazone binds to and results in increased activity of PPARG protein] which results in decreased expression of SREBF2 protein

PMID:16946405
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.