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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 737494
Species: Homo sapiens
CRRD Object: Gene
Symbol: SYP
Name: synaptophysin
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:113736480464CTDValsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]

PMID:18487452
multiple interactionsISORGD:38026480464CTDValsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein], Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]

PMID:18487452
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.