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Gene: Adrb1 (adrenergic receptor, beta 1) Mus musculus
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Symbol: Adrb1
Name: adrenergic receptor, beta 1
Description: Exhibits G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and beta1-adrenergic receptor activity. Involved in several processes, including brown fat cell differentiation; diet induced thermogenesis; and regulation of systemic arterial blood pressure by norepinephrine-epinephrine. Localizes to the Schaffer collateral - CA1 synapse and membrane. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; intestine; and liver and biliary system. Orthologous to human ADRB1 (adrenoceptor beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; 5-azacytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Adrb-1; beta 1-AR; beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; beta-AR; cardiac beta adrenergic receptor
Orthologs:
Homo sapiens (human) : ADRB1 (adrenoceptor beta 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Adrb1 (adrenoceptor beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adrb1 (adrenoceptor beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRB1 (adrenoceptor beta 1)
Canis lupus familiaris (dog) : ADRB1 (adrenoceptor beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adrb1 (adrenoceptor beta 1)
Sus scrofa (pig) : ADRB1 (adrenoceptor beta 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381956,722,117 - 56,725,150 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371956,796,862 - 56,799,352 (+)NCBIGRCm37mm9NCBIm37
MGSCv361956,775,622 - 56,777,022 (+)NCBImm8
Celera1958,910,911 - 58,913,400 (+)NCBICelera
Cytogenetic Map19 D2NCBI
cM Map1951.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Adrb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10106
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.