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Gene: Grk2 (G protein-coupled receptor kinase 2) Mus musculus
Symbol: Grk2
Name: G protein-coupled receptor kinase 2
Description: Exhibits G protein-coupled receptor kinase activity. Involved in several processes, including desensitization of G protein-coupled receptor signaling pathway; protein phosphorylation; and regulation of the force of heart contraction. Localizes to the membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and mesenchyme derived from neural crest. Orthologous to human GRK2 (G protein-coupled receptor kinase 2); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Adrbk-1; Adrbk1; adrenergic receptor kinase, beta 1; Bark-1; beta ARK; beta ARK1; beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase-1; beta-AR kinase-1; beta-ARK-1; betaARK1; G-protein-coupled receptor kinase 2
Homo sapiens (human) : GRK2 (G protein-coupled receptor kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Grk2 (G protein-coupled receptor kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk2 (G protein-coupled receptor kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK2 (G protein-coupled receptor kinase 2)
Canis lupus familiaris (dog) : GRK2 (G protein-coupled receptor kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk2 (G protein-coupled receptor kinase 2)
Sus scrofa (pig) : GRK2 (G protein-coupled receptor kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38194,285,999 - 4,306,222 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37194,286,001 - 4,305,955 (-)NCBIGRCm37mm9NCBIm37
MGSCv36194,286,001 - 4,305,955 (-)NCBImm8
Celera194,157,226 - 4,177,339 (-)NCBICelera
Cytogenetic Map19 ANCBI
cM Map193.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Grk2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10111
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.