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Gene: Agt (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) Mus musculus
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Symbol: Agt
Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
CRRD ID: 10118
Description: Exhibits type 1 angiotensin receptor binding activity and type 2 angiotensin receptor binding activity. Involved in several processes, including nervous system development; positive regulation of protein phosphorylation; and regulation of systemic arterial blood pressure by renin-angiotensin. Localizes to extracellular space. Is expressed in several structures, including axial skeleton; central nervous system; foregut mesenchyme; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway via AT2 receptor; angiotensin III signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-taxifolin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI265500; AngI; AngII; angiotensin I; angiotensin ll; angiotensinogen; Ao; Aogen; Se; serpin A8; Serpina8
Orthologs:
Homo sapiens (human) : AGT (angiotensinogen)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Agt (angiotensinogen)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Agt (angiotensinogen)
Pan paniscus (bonobo/pygmy chimpanzee) : AGT (angiotensinogen)
Canis lupus familiaris (dog) : AGT (angiotensinogen)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Agt (angiotensinogen)
Sus scrofa (pig) : AGT (angiotensinogen)
Chlorocebus sabaeus (African green monkey) : AGT (angiotensinogen)
Heterocephalus glaber (naked mole-rat) : Agt (angiotensinogen)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBImm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Protein Structures
Promoters

Additional Information

External Database Links
 
More on Agt
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10118
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.