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Gene: Akt2 (thymoma viral proto-oncogene 2) Mus musculus
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Symbol: Akt2
Name: thymoma viral proto-oncogene 2
Description: Exhibits protein serine/threonine kinase activity. Involved in several processes, including activation of GTPase activity; cellular response to high light intensity; and positive regulation of transport. Localizes to the cell cortex and ruffle membrane. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); malignant glioma; and reproductive organ cancer (multiple). Is expressed in brown fat; central nervous system; early conceptus; genitourinary system; and retina. Orthologous to human AKT2 (AKT serine/threonine kinase 2); PARTICIPATES IN altered insulin responsive facilitative sugar transporter mediated glucose transport pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; E-cadherin signaling pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2410016A19Rik; AW554154; MGC14031; PKB; PKB beta; PKBbeta; protein kinase Akt-2; protein kinase B beta; protein kinase B, beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta
Orthologs:
Homo sapiens (human) : AKT2 (AKT serine/threonine kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Akt2 (AKT serine/threonine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akt2 (AKT serine/threonine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AKT2 (AKT serine/threonine kinase 2)
Canis lupus familiaris (dog) : AKT2 (AKT serine/threonine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akt2 (AKT serine/threonine kinase 2)
Sus scrofa (pig) : AKT2 (AKT serine/threonine kinase 2)
Chlorocebus sabaeus (green monkey) : AKT2 (AKT serine/threonine kinase 2)
Heterocephalus glaber (naked mole-rat) : Akt2 (AKT serine/threonine kinase 2)
more info ...
Related Pseudogenes: Akt2-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl727,591,552 - 27,640,826 (+)Ensembl
GRCm38727,591,552 - 27,640,826 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37728,376,579 - 28,424,472 (+)NCBIGRCm37mm9NCBIm37
MGSCv36727,314,618 - 27,348,214 (+)NCBImm8
Celera722,173,505 - 22,221,607 (+)NCBICelera
Cytogenetic Map7 A3NCBI
cM Map715.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
 
More on Akt2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10132
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.