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Gene: Atp1a1 (ATPase, Na+/K+ transporting, alpha 1 polypeptide) Mus musculus
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Symbol: Atp1a1
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Description: Exhibits phosphatase activity and sodium:potassium-exchanging ATPase activity. Involved in several processes, including negative regulation of glucocorticoid biosynthetic process; positive regulation of striated muscle contraction; and regulation of heart contraction. Localizes to several cellular components, including the T-tubule; basolateral plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Atpa-1; BC010319; MGC38419; Na(+)/K(+) ATPase alpha-1 subunit; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase subunit alpha-1
Orthologs:
Homo sapiens (human) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Canis lupus familiaris (dog) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)
Sus scrofa (pig) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Chlorocebus sabaeus (green monkey) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Heterocephalus glaber (naked mole-rat) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl3101,576,219 - 101,604,684 (-)Ensembl
GRCm383101,576,219 - 101,604,707 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373101,380,146 - 101,408,580 (-)NCBIGRCm37mm9NCBIm37
MGSCv363101,705,284 - 101,733,721 (-)NCBImm8
Celera3103,788,089 - 103,816,578 (-)NCBICelera
Cytogenetic Map3 F2.2NCBI
cM Map344.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Atp1a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10203
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.