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Gene: Atp1a1 (ATPase, Na+/K+ transporting, alpha 1 polypeptide) Mus musculus
Symbol: Atp1a1
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Description: Exhibits phosphatase activity and sodium:potassium-exchanging ATPase activity. Involved in several processes, including negative regulation of glucocorticoid biosynthetic process; positive regulation of striated muscle contraction; and regulation of heart contraction. Localizes to several cellular components, including the T-tubule; basolateral plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Atpa-1; BC010319; MGC38419; Na(+)/K(+) ATPase alpha-1 subunit; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase subunit alpha-1
Homo sapiens (human) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Canis lupus familiaris (dog) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)
Sus scrofa (pig) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Chlorocebus sabaeus (green monkey) : ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)
Heterocephalus glaber (naked mole-rat) : Atp1a1 (ATPase Na+/K+ transporting subunit alpha 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl3101,576,219 - 101,604,684 (-)Ensembl
GRCm383101,576,219 - 101,604,707 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373101,380,146 - 101,408,580 (-)NCBIGRCm37mm9NCBIm37
MGSCv363101,705,284 - 101,733,721 (-)NCBImm8
Celera3103,788,089 - 103,816,578 (-)NCBICelera
Cytogenetic Map3 F2.2NCBI
cM Map344.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Atp1a1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10203
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.