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Gene: Atp7a (ATPase, Cu++ transporting, alpha polypeptide) Mus musculus
Symbol: Atp7a
Name: ATPase, Cu++ transporting, alpha polypeptide
Description: Exhibits copper transmembrane transporter activity, phosphorylative mechanism and superoxide dismutase copper chaperone activity. Involved in several processes, including animal organ development; catecholamine metabolic process; and copper ion transport. Localizes to several cellular components, including cytoplasmic vesicle; neuronal cell body; and trans-Golgi network. Is expressed in several structures, including genitourinary system; gut mucosa; liver; spleen; and thoracic ganglion. Used to study Menkes disease; X-linked distal spinal muscular atrophy 3; aortic aneurysm; and osteoarthritis. Human ortholog(s) of this gene implicated in Menkes disease; X-linked distal spinal muscular atrophy 3; cutis laxa; and occipital horn syndrome. Orthologous to human ATP7A (ATPase copper transporting alpha); PARTICIPATES IN cisplatin drug pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Blo; blotchy; br; brindled; copper pump 1; copper-transporting ATPase 1; DXHXS1608e; I14; menkes disease-associated protein homolog; Menkes protein; MNK; Mo; mottled
Homo sapiens (human) : ATP7A (ATPase copper transporting alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Atp7a (ATPase copper transporting alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp7a (ATPase copper transporting alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP7A (ATPase copper transporting alpha)
Canis lupus familiaris (dog) : ATP7A (ATPase copper transporting alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp7a (ATPase copper transporting alpha)
Sus scrofa (pig) : ATP7A (ATPase copper transporting alpha)
Chlorocebus sabaeus (African green monkey) : ATP7A (ATPase copper transporting alpha)
Heterocephalus glaber (naked mole-rat) : Atp7a (ATPase copper transporting alpha)
more info ...
Related Pseudogenes: Atp7a-rs1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 EnsemblX106,027,276 - 106,124,926 (+)EnsemblGRCm38mm10GRCm38
GRCm38X106,027,224 - 106,128,161 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X103,222,615 - 103,323,499 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X102,230,036 - 102,327,636 (+)NCBImm8
CeleraX92,880,992 - 92,982,185 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Atp7a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10215
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.