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Gene: B2m (beta-2 microglobulin) Mus musculus
Symbol: B2m
Name: beta-2 microglobulin
Description: Predicted to have protein homodimerization activity. Involved in several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cellular response to iron(III) ion; and negative regulation of neuron differentiation. Localizes to the external side of plasma membrane. Used to study hemochromatosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in arthritis; familial visceral amyloidosis; inflammatory bowel disease; and primary immunodeficiency disease. Is expressed in brain; early conceptus; germ cell of ovary; and liver. Orthologous to human B2M (beta-2-microglobulin); PARTICIPATES IN interleukin-12 signaling pathway; antigen processing and presentation pathway; INTERACTS WITH 1,1-dichloroethene; 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta 2 microglobulin; beta-2-microglobulin; beta2-m; beta2m; Ly-m11
Homo sapiens (human) : B2M (beta-2-microglobulin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : B2m (beta-2 microglobulin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : B2m (beta-2-microglobulin)
Pan paniscus (bonobo/pygmy chimpanzee) : B2M (beta-2-microglobulin)
Canis lupus familiaris (dog) : B2M (beta-2-microglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : B2m (beta-2-microglobulin)
Sus scrofa (pig) : B2M (beta-2-microglobulin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382122,147,687 - 122,153,082 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372121,973,423 - 121,978,818 (+)NCBIGRCm37mm9NCBIm37
MGSCv362121,839,128 - 121,844,523 (+)NCBImm8
Celera2123,294,935 - 123,300,323 (+)NCBICelera
Cytogenetic Map2 E5NCBI
cM Map260.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on B2m
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10224
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.