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Gene: B2m (beta-2 microglobulin) Mus musculus
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Symbol: B2m
Name: beta-2 microglobulin
Description: Predicted to have protein homodimerization activity. Involved in several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cellular response to iron(III) ion; and negative regulation of neuron differentiation. Localizes to the external side of plasma membrane. Used to study hemochromatosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in arthritis; familial visceral amyloidosis; inflammatory bowel disease; and primary immunodeficiency disease. Is expressed in brain; early conceptus; germ cell of ovary; and liver. Orthologous to human B2M (beta-2-microglobulin); PARTICIPATES IN interleukin-12 signaling pathway; antigen processing and presentation pathway; INTERACTS WITH 1,1-dichloroethene; 1-chloro-2,4-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta 2 microglobulin; beta-2-microglobulin; beta2-m; beta2m; Ly-m11
Orthologs:
Homo sapiens (human) : B2M (beta-2-microglobulin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : B2m (beta-2 microglobulin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : B2m (beta-2-microglobulin)
Pan paniscus (bonobo/pygmy chimpanzee) : B2M (beta-2-microglobulin)
Canis lupus familiaris (dog) : B2M (beta-2-microglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : B2m (beta-2-microglobulin)
Sus scrofa (pig) : B2M (beta-2-microglobulin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382122,147,687 - 122,153,082 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372121,973,423 - 121,978,818 (+)NCBIGRCm37mm9NCBIm37
MGSCv362121,839,128 - 121,844,523 (+)NCBImm8
Celera2123,294,935 - 123,300,323 (+)NCBICelera
Cytogenetic Map2 E5NCBI
cM Map260.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on B2m
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10224
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.