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Gene: Bmp4 (bone morphogenetic protein 4) Mus musculus
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Symbol: Bmp4
Name: bone morphogenetic protein 4
Description: Exhibits heparin binding activity. Involved in several processes, including animal organ development; regulation of animal organ morphogenesis; and regulation of transcription by RNA polymerase II. Localizes to extracellular space. Used to study Axenfeld-Rieger syndrome type 3; atrioventricular septal defect; cleft palate-lateral synechia syndrome; fibrodysplasia ossificans progressiva; and urinary system disease. Human ortholog(s) of this gene implicated in several diseases, including CAKUT (multiple); cleft lip; orofacial cleft 11; ossification of the posterior longitudinal ligament of spine; and otosclerosis. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human BMP4 (bone morphogenetic protein 4).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMP-2B; Bmp-4; Bmp2b; Bmp2b-1; Bmp2b1; bone morphogenetic protein 2B
Orthologs:
Homo sapiens (human) : BMP4 (bone morphogenetic protein 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Bmp4 (bone morphogenetic protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmp4 (bone morphogenetic protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : BMP4 (bone morphogenetic protein 4)
Canis lupus familiaris (dog) : BMP4 (bone morphogenetic protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bmp4 (bone morphogenetic protein 4)
Sus scrofa (pig) : BMP4 (bone morphogenetic protein 4)
Chlorocebus sabaeus (African green monkey) : BMP4 (bone morphogenetic protein 4)
Heterocephalus glaber (naked mole-rat) : Bmp4 (bone morphogenetic protein 4)
more info ...
Related Pseudogenes: Bmp4-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1446,383,520 - 46,390,669 (-)EnsemblGRCm38mm10GRCm38
GRCm381446,383,525 - 46,390,669 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371447,003,195 - 47,010,274 (-)NCBIGRCm37mm9NCBIm37
MGSCv361445,305,736 - 45,309,065 (-)NCBImm8
Celera1442,555,453 - 42,562,519 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1423.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Bmp4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10244
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.