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Gene: C2 (complement component 2 (within H-2S)) Mus musculus
Symbol: C2
Name: complement component 2 (within H-2S)
CRRD ID: 10255
Description: Predicted to have metal ion binding activity and serine-type endopeptidase activity. Predicted to be involved in complement activation and positive regulation of apoptotic cell clearance. Localizes to extracellular space. Is expressed in liver and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; age related macular degeneration 14; complement component 2 deficiency; macular degeneration; and psoriasis. Orthologous to human C2 (complement C2).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C3/C5 convertase; classical-complement pathway C3/C5 convertase; complement C2; complement component C2; complement factor C2; MHC complement component C2
Homo sapiens (human) : C2 (complement C2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : C2 (complement C2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : C2 (complement C2)
Pan paniscus (bonobo/pygmy chimpanzee) : C2 (complement C2)
Canis lupus familiaris (dog) : C2 (complement C2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : C2 (complement C2)
Sus scrofa (pig) : C2 (complement C2)
Heterocephalus glaber (naked mole-rat) : C2 (complement C2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391735,081,578 - 35,101,076 (-)NCBI
GRCm381734,862,602 - 34,882,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,862,604 - 34,898,265 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,999,547 - 35,019,045 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,470,663 - 34,490,103 (-)NCBImm8
Celera1737,957,910 - 37,977,407 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on C2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10255
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.