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Gene: C4b (complement component 4B (Chido blood group)) Mus musculus
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Symbol: C4b
Name: complement component 4B (Chido blood group)
Description: Predicted to have carbohydrate binding activity and complement component C1q binding activity. Involved in complement activation and immunoglobulin mediated immune response. Localizes to the extracellular space. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune hypersensitivity disease (multiple); complement deficiency (multiple); renal cell carcinoma; and rheumatoid arthritis. Is expressed in brain; liver; and reproductive system. Orthologous to several human genes including C4A (complement C4A (Rodgers blood group)); PARTICIPATES IN classical complement pathway; coagulation cascade pathway; complement system pathway; INTERACTS WITH (R)-lipoic acid; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C4; complement C4-B; complement component 4 (within H-2S); complement component 4B (Childo blood group); Ss
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381734,728,139 - 34,743,902 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371734,865,325 - 34,880,842 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,336,443 - 34,351,939 (-)NCBImm8
Celera1737,826,575 - 37,840,058 (-)NCBICelera
Cytogenetic Map17 B1NCBI
cM Map1718.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on C4b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10257
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.