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Gene: Cd28 (CD28 antigen) Mus musculus
Symbol: Cd28
Name: CD28 antigen
Description: Exhibits protein kinase binding activity. Involved in several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Localizes to the external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule); PARTICIPATES IN allograft rejection pathway; autoimmune thyroiditis pathway; graft-versus-host disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetohydrazide; acrolein.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: T-cell-specific surface glycoprotein CD28
Homo sapiens (human) : CD28 (CD28 molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd28 (Cd28 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd28 (CD28 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD28 (CD28 molecule)
Canis lupus familiaris (dog) : CD28 (CD28 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd28 (CD28 molecule)
Sus scrofa (pig) : CD28 (CD28 molecule)
Chlorocebus sabaeus (African green monkey) : CD28 (CD28 molecule)
Heterocephalus glaber (naked mole-rat) : Cd28 (CD28 molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl160,716,800 - 60,773,359 (+)EnsemblGRCm38mm10GRCm38
GRCm38160,746,388 - 60,773,359 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37160,803,232 - 60,830,203 (+)NCBIGRCm37mm9NCBIm37
MGSCv36160,691,012 - 60,717,905 (+)NCBImm8
Celera161,261,669 - 61,288,639 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cd28
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10307
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.