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Gene: Cd4 (CD4 antigen) Mus musculus
Symbol: Cd4
Name: CD4 antigen
Description: Predicted to have several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in several processes, including defense response to Gram-negative bacterium; helper T cell enhancement of adaptive immune response; and positive regulation of peptidyl-tyrosine phosphorylation. Localizes to several cellular components, including the endoplasmic reticulum lumen; external side of plasma membrane; and membrane raft. Used to study type 1 diabetes mellitus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human CD4 (CD4 molecule); PARTICIPATES IN Arf family mediated signaling pathway; interleukin-12 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-catechin; 1,2-dichloroethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L3T4; Ly-4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)
Homo sapiens (human) : CD4 (CD4 molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd4 (Cd4 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd4 (CD4 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD4 (CD4 molecule)
Canis lupus familiaris (dog) : CD4 (CD4 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd4 (CD4 molecule)
Sus scrofa (pig) : CD4 (CD4 molecule)
Chlorocebus sabaeus (African green monkey) : CD4 (CD4 molecule)
Heterocephalus glaber (naked mole-rat) : Cd4 (CD4 molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl6124,864,692 - 124,888,221 (-)EnsemblGRCm38mm10GRCm38
GRCm386124,864,693 - 124,888,247 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376124,814,711 - 124,838,227 (-)NCBIGRCm37mm9NCBIm37
MGSCv366124,830,312 - 124,853,828 (-)NCBImm8
Celera6126,540,818 - 126,564,333 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cd4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10309
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.