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Gene: Cd4 (CD4 antigen) Mus musculus
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Symbol: Cd4
Name: CD4 antigen
Description: Predicted to have several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in several processes, including defense response to Gram-negative bacterium; helper T cell enhancement of adaptive immune response; and positive regulation of peptidyl-tyrosine phosphorylation. Localizes to several cellular components, including the endoplasmic reticulum lumen; external side of plasma membrane; and membrane raft. Used to study type 1 diabetes mellitus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human CD4 (CD4 molecule); PARTICIPATES IN Arf family mediated signaling pathway; interleukin-12 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-catechin; 1,2-dichloroethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L3T4; Ly-4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)
Orthologs:
Homo sapiens (human) : CD4 (CD4 molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd4 (Cd4 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd4 (CD4 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD4 (CD4 molecule)
Canis lupus familiaris (dog) : CD4 (CD4 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd4 (CD4 molecule)
Sus scrofa (pig) : CD4 (CD4 molecule)
Chlorocebus sabaeus (African green monkey) : CD4 (CD4 molecule)
Heterocephalus glaber (naked mole-rat) : Cd4 (CD4 molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl6124,864,692 - 124,888,221 (-)EnsemblGRCm38mm10GRCm38
GRCm386124,864,693 - 124,888,247 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376124,814,711 - 124,838,227 (-)NCBIGRCm37mm9NCBIm37
MGSCv366124,830,312 - 124,853,828 (-)NCBImm8
Celera6126,540,818 - 126,564,333 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cd4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10309
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.