Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cdkn2a (cyclin dependent kinase inhibitor 2A) Mus musculus
Analyze
Symbol: Cdkn2a
Name: cyclin dependent kinase inhibitor 2A
Description: Exhibits MDM2/MDM4 family protein binding activity; enzyme inhibitor activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of cellular protein metabolic process; and positive regulation of apoptotic process. Localizes to cytoplasm; granular component; and protein-containing complex. Predicted to colocalize with nuclear body. Is expressed in several structures, including bone marrow; central nervous system; dorsal root ganglion; eye; and testis. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); and nervous system cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A); PARTICIPATES IN altered G1/S transition pathway; G1/S transition pathway; pancreatic cancer pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alternative reading frame; Arf; ARF-INK4a; CDK4I; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoforms 1/2; cyclin-dependent kinase inhibitor protein; INK4a-ARF; Ink4a/Arf; mitochondrial smARF; MTS1; p16; p16(INK4a); p16-INK4; p16-INK4a; p16INK4a; p19; p19ARF; Pctr1
Orthologs:
Homo sapiens (human) : CDKN2A (cyclin dependent kinase inhibitor 2A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cdkn2a (cyclin-dependent kinase inhibitor 2A)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN2A (cyclin dependent kinase inhibitor 2A)
Sus scrofa (pig) : P14ARF (p14ARF protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl489,274,471 - 89,294,653 (-)EnsemblGRCm38mm10GRCm38
GRCm38489,274,473 - 89,294,619 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37488,920,377 - 88,940,523 (-)NCBIGRCm37mm9NCBIm37
MGSCv36488,745,868 - 88,765,796 (-)NCBImm8
Celera487,760,902 - 87,780,610 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map442.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated