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Gene: Cftr (cystic fibrosis transmembrane conductance regulator) Mus musculus
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Symbol: Cftr
Name: cystic fibrosis transmembrane conductance regulator
Description: Exhibits bicarbonate transmembrane transporter activity and chloride channel activity. Involved in several processes, including cellular response to cAMP; membrane hyperpolarization; and positive regulation of transport. Localizes to the apical plasma membrane; cytosol; and integral component of plasma membrane. Used to study cystic fibrosis. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); cystic fibrosis; and lung disease (multiple). Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CFTR (CF transmembrane conductance regulator).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Abcc7; ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; ATP-binding cassette, subfamily c, member 7; AW495489; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator homolog
Orthologs:
Homo sapiens (human) : CFTR (CF transmembrane conductance regulator)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cftr (CF transmembrane conductance regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cftr (CF transmembrane conductance regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CFTR (CF transmembrane conductance regulator)
Canis lupus familiaris (dog) : CFTR (CF transmembrane conductance regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cftr (CF transmembrane conductance regulator)
Sus scrofa (pig) : CFTR (CF transmembrane conductance regulator)
Chlorocebus sabaeus (green monkey) : CFTR (CF transmembrane conductance regulator)
Heterocephalus glaber (naked mole-rat) : Cftr (CF transmembrane conductance regulator)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl618,170,687 - 18,322,768 (+)Ensembl
GRCm38618,170,687 - 18,322,770 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37618,120,687 - 18,272,770 (+)NCBIGRCm37mm9NCBIm37
MGSCv36618,120,687 - 18,272,767 (+)NCBImm8
Celera618,244,038 - 18,394,318 (+)NCBICelera
Cytogenetic Map6 A2NCBI
cM Map68.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated