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Gene: CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit) Homo sapiens
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Symbol: CHRNA4
Name: cholinergic receptor nicotinic alpha 4 subunit
Description: Exhibits acetylcholine receptor activity and acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine binding activity and extracellular ligand-gated ion channel activity. Involved in several processes, including DNA repair; behavioral response to nicotine; and response to hypoxia. Localizes to the acetylcholine-gated channel complex. Implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Biomarker of Alzheimer's disease and Lewy body dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acetylcholine receptor, nicotinic, alpha 4 (neuronal); BFNC; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 4; EBN; EBN1; FLJ95812; NACHR; NACHRA4; NACRA4; neuronal acetylcholine receptor subunit alpha-4; neuronal nicotinic acetylcholine receptor alpha-4 subunit
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,343,223 - 63,375,471 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372061,974,662 - 62,009,487 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,445,109 - 61,463,192 (-)NCBINCBI36hg18NCBI36
Build 342061,446,464 - 61,463,192NCBI
Celera2058,652,104 - 58,670,128 (-)NCBI
Cytogenetic Map20q13.33NCBI
HuRef2058,700,254 - 58,717,202 (-)NCBIHuRef
CHM1_12061,875,694 - 61,893,903 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CHRNA4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10356
Created: 2000-05-25
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.