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Gene: Ctsc (cathepsin C) Mus musculus
Symbol: Ctsc
Name: cathepsin C
Description: Exhibits cysteine-type peptidase activity; peptidase activator activity involved in apoptotic process; and serine-type endopeptidase activity. Involved in several processes, including T cell mediated cytotoxicity; negative regulation of myelination; and positive regulation of microglial cell activation. Localizes to cytoplasm. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human CTSC (cathepsin C).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI047818; CatC; cathepsin J; dipeptidyl peptidase 1; dipeptidyl peptidase I; dipeptidyl transferase; dipeptidyl-peptidase 1; dipeptidyl-peptidase I; dipeptidylpeptidase 1; DPP-I; DPP1; DPPI
Homo sapiens (human) : CTSC (cathepsin C)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ctsc (cathepsin C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctsc (cathepsin C)
Pan paniscus (bonobo/pygmy chimpanzee) : CTSC (cathepsin C)
Canis lupus familiaris (dog) : CTSC (cathepsin C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctsc (cathepsin C)
Sus scrofa (pig) : CTSC (cathepsin C)
Chlorocebus sabaeus (African green monkey) : CTSC (cathepsin C)
Heterocephalus glaber (naked mole-rat) : Ctsc (cathepsin C)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl788,278,085 - 88,310,888 (+)EnsemblGRCm38mm10GRCm38
GRCm38788,278,024 - 88,315,861 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37795,426,603 - 95,459,385 (+)NCBIGRCm37mm9NCBIm37
MGSCv36788,153,327 - 88,186,080 (+)NCBImm8
Celera785,627,464 - 85,661,039 (+)NCBICelera
Cytogenetic Map7D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ctsc
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10421
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.