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Gene: Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1) Mus musculus
Symbol: Cyp11b1
Name: cytochrome P450, family 11, subfamily b, polypeptide 1
Description: Exhibits corticosterone 18-monooxygenase activity. Involved in glucocorticoid biosynthetic process. Localizes to mitochondrion. Is expressed in adrenal gland; gland; lung; and testis. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA389061; CPN1; Cyp11b; Cyp11b-1; FHI; steroid-11-beta-hydroxylase
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1574,834,125 - 74,841,643 (-)EnsemblGRCm38mm10GRCm38
GRCm381574,834,892 - 74,841,643 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371574,665,322 - 74,672,073 (-)NCBIGRCm37mm9NCBIm37
MGSCv361574,662,150 - 74,668,874 (-)NCBImm8
Celera1576,341,146 - 76,348,165 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cyp11b1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10428
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.