Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1) Mus musculus
Analyze
Symbol: Cyp11b1
Name: cytochrome P450, family 11, subfamily b, polypeptide 1
Description: Exhibits corticosterone 18-monooxygenase activity. Involved in glucocorticoid biosynthetic process. Localizes to mitochondrion. Is expressed in adrenal gland; gland; lung; and testis. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA389061; CPN1; Cyp11b; Cyp11b-1; FHI; steroid-11-beta-hydroxylase
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1574,834,125 - 74,841,643 (-)EnsemblGRCm38mm10GRCm38
GRCm381574,834,892 - 74,841,643 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371574,665,322 - 74,672,073 (-)NCBIGRCm37mm9NCBIm37
MGSCv361574,662,150 - 74,668,874 (-)NCBImm8
Celera1576,341,146 - 76,348,165 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cyp11b1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10428
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.