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Gene: Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1) Mus musculus
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
CRRD ID: 10439
Description: Exhibits oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including blood vessel morphogenesis; cellular response to oxidative stress; and retinoid metabolic process. Localizes to mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (cytochrome P450 family 1 subfamily B member 1); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; steroid hormone biosynthetic pathway; tryptophan metabolic pathway; INTERACTS WITH (S)-naringenin; 1,2,3,7,8-Pentachlorodibenzodioxin; 1,4-dihydroxy-2-naphthoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: benz[a]anthracene inducible; CP1B; CYPIB1; cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450CMEF; cytochrome P450EF; hydroperoxy icosatetraenoate dehydratase; P4501b1
Homo sapiens (human) : CYP1B1 (cytochrome P450 family 1 subfamily B member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyp1b1 (cytochrome P450, family 1, subfamily b, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102009223 (cytochrome P450 1B1)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP1B1 (cytochrome P450 family 1 subfamily B member 1)
Canis lupus familiaris (dog) : CYP1B1 (cytochrome P450 family 1 subfamily B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101970101 (cytochrome P450 1B1)
Sus scrofa (pig) : LOC100625479 (cytochrome P450 1B1)
Chlorocebus sabaeus (African green monkey) : CYP1B1 (cytochrome P450 family 1 subfamily B member 1)
Heterocephalus glaber (naked mole-rat) : LOC101701066 (cytochrome P450 1B1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391780,014,369 - 80,022,490 (-)NCBI
GRCm381779,706,940 - 79,715,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,701,537 - 79,715,061 (-)EnsemblGRCm38mm10GRCm38
MGSCv371780,106,293 - 80,114,381 (-)NCBIGRCm37mm9NCBIm37
MGSCv361779,615,279 - 79,623,367 (-)NCBImm8
Celera1784,018,414 - 84,026,502 (-)NCBICelera
Cytogenetic Map17E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cyp1b1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10439
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.