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Gene: Cyp21a1 (cytochrome P450, family 21, subfamily a, polypeptide 1) Mus musculus
Symbol: Cyp21a1
Name: cytochrome P450, family 21, subfamily a, polypeptide 1
Description: Predicted to have heme binding activity and steroid 21-monooxygenase activity. Predicted to be involved in progesterone metabolic process and steroid hormone biosynthetic process. Predicted to localize to endoplasmic reticulum and membrane. Is expressed in several structures, including adrenal gland; lung; metanephros; spleen; and testis. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to several human genes including CYP21A2 (cytochrome P450 family 21 subfamily A member 2); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 21-hydroxylase; 21-OH; 21-OHase; 21OH; 21OHA; 21OHB; Cyp21; Cyp21-ps1; Cyp21a2-ps; Cyp21a2ps; Cyp21B; CYP21OH-A; cytochrome P-450; cytochrome P-450c21; cytochrome P450 21; cytochrome P450 hydroxylase A; cytochrome P450 XXI; cytochrome P450, 21, pseudogene; cytochrome P450, 21, steroid 21 hydroxylase; cytochrome P450, family 21, subfamily a, polypeptide 2, pseudogene; cytochrome P450-C21; MGC156449; Oh21-1; Oh21-2; steroid 21 hydroxylase; steroid 21-hydroxylase
Homo sapiens (human) : CYP21A2 (cytochrome P450 family 21 subfamily A member 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyp21a1 (cytochrome P450, family 21, subfamily a, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102008255 (steroid 21-hydroxylase)
Canis lupus familiaris (dog) : CYP21A2 (cytochrome P450c21)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101977414 (steroid 21-hydroxylase)
Sus scrofa (pig) : CYP21A2 (cytochrome P450, family 21, subfamily A, polypepide 2)
Chlorocebus sabaeus (African green monkey) : CYP21A2 (cytochrome P450 family 21 subfamily A member 2)
Heterocephalus glaber (naked mole-rat) : LOC101717066 (steroid 21-hydroxylase)
more info ...
Related Pseudogenes: Cyp21a2-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1734,801,348 - 34,804,561 (-)EnsemblGRCm38mm10GRCm38
GRCm381734,801,348 - 34,804,426 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371734,938,293 - 34,941,371 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,409,836 - 34,412,455 (-)NCBImm8
Celera1737,896,632 - 37,899,713 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cyp21a1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10440
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.