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Gene: Cyp7b1 (cytochrome P450, family 7, subfamily b, polypeptide 1) Mus musculus
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Symbol: Cyp7b1
Name: cytochrome P450, family 7, subfamily b, polypeptide 1
CRRD ID: 10459
Description: Exhibits oxysterol 7-alpha-hydroxylase activity. Involved in several processes, including B cell chemotaxis; bile acid biosynthetic process; and negative regulation of intracellular estrogen receptor signaling pathway. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-dexrazoxane; (2,4,5-trichlorophenoxy)acetic acid; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; AW261589; cytochrome P450 7B1; cytochrome P450, 7b1; D3Ertd552; D3Ertd552e; hct-1; hippocampal transcript 1 protein; oxysterol 7-alpha-hydroxylase
Orthologs:
Homo sapiens (human) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyp7b1 (cytochrome P450 family 7 subfamily B member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102022645 (25-hydroxycholesterol 7-alpha-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)
Canis lupus familiaris (dog) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101955077 (25-hydroxycholesterol 7-alpha-hydroxylase)
Sus scrofa (pig) : LOC100738003 (25-hydroxycholesterol 7-alpha-hydroxylase-like)
Chlorocebus sabaeus (African green monkey) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)
Heterocephalus glaber (naked mole-rat) : LOC101721563 (25-hydroxycholesterol 7-alpha-hydroxylase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39318,126,108 - 18,298,054 (-)NCBI
GRCm38318,071,944 - 18,243,890 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl318,071,950 - 18,243,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv37317,971,950 - 18,143,338 (-)NCBIGRCm37mm9NCBIm37
MGSCv36318,264,101 - 18,435,480 (-)NCBImm8
Celera318,067,760 - 18,239,527 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map34.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cyp7b1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10459
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.