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Gene: Cyp7b1 (cytochrome P450, family 7, subfamily b, polypeptide 1) Mus musculus
Symbol: Cyp7b1
Name: cytochrome P450, family 7, subfamily b, polypeptide 1
CRRD ID: 10459
Description: Exhibits oxysterol 7-alpha-hydroxylase activity. Involved in several processes, including B cell chemotaxis; bile acid biosynthetic process; and negative regulation of intracellular estrogen receptor signaling pathway. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-dexrazoxane; (2,4,5-trichlorophenoxy)acetic acid; (25R)-cholest-5-ene-3beta,26-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 24-hydroxycholesterol 7-alpha-hydroxylase; 25-hydroxycholesterol 7-alpha-hydroxylase; 25/26-hydroxycholesterol 7-alpha-hydroxylase; 3-hydroxysteroid 7-alpha hydroxylase; AW261589; cytochrome P450 7B1; cytochrome P450, 7b1; D3Ertd552; D3Ertd552e; hct-1; hippocampal transcript 1 protein; oxysterol 7-alpha-hydroxylase
Homo sapiens (human) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cyp7b1 (cytochrome P450 family 7 subfamily B member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102022645 (25-hydroxycholesterol 7-alpha-hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)
Canis lupus familiaris (dog) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101955077 (25-hydroxycholesterol 7-alpha-hydroxylase)
Sus scrofa (pig) : LOC100738003 (25-hydroxycholesterol 7-alpha-hydroxylase-like)
Chlorocebus sabaeus (African green monkey) : CYP7B1 (cytochrome P450 family 7 subfamily B member 1)
Heterocephalus glaber (naked mole-rat) : LOC101721563 (25-hydroxycholesterol 7-alpha-hydroxylase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39318,126,108 - 18,298,054 (-)NCBI
GRCm38318,071,944 - 18,243,890 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl318,071,950 - 18,243,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv37317,971,950 - 18,143,338 (-)NCBIGRCm37mm9NCBIm37
MGSCv36318,264,101 - 18,435,480 (-)NCBImm8
Celera318,067,760 - 18,239,527 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map34.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cyp7b1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10459
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.