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Gene: Dhfr (dihydrofolate reductase) Mus musculus
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Symbol: Dhfr
Name: dihydrofolate reductase
Description: Exhibits dihydrofolate reductase activity. Involved in positive regulation of nitric-oxide synthase activity; regulation of removal of superoxide radicals; and tetrahydrobiopterin biosynthetic process. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Orthologous to several human genes including DHFRP1 (dihydrofolate reductase pseudogene 1); PARTICIPATES IN altered folate cycle metabolic pathway; dopa responsive dystonia pathway; folate cycle metabolic pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 8430436I03Rik; AA607882; AI662710; AW555094
Orthologs:
Homo sapiens (human) : DHFR (dihydrofolate reductase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dhfr (dihydrofolate reductase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dhfr (dihydrofolate reductase)
Pan paniscus (bonobo/pygmy chimpanzee) : DHFR (dihydrofolate reductase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dhfr (dihydrofolate reductase)
Sus scrofa (pig) : DHFR (dihydrofolate reductase)
Chlorocebus sabaeus (African green monkey) : DHFR (dihydrofolate reductase)
Heterocephalus glaber (naked mole-rat) : Dhfr (dihydrofolate reductase)
more info ...
Related Pseudogenes: Dhfr-rs1   Gm18226  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1392,354,726 - 92,389,053 (+)EnsemblGRCm38mm10GRCm38
GRCm381392,354,783 - 92,389,053 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371393,124,738 - 93,159,008 (+)NCBIGRCm37mm9NCBIm37
MGSCv361393,455,536 - 93,489,806 (+)NCBImm8
Celera1395,961,012 - 95,994,907 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dhfr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10471
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.