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Gene: Drd4 (dopamine receptor D4) Mus musculus
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Symbol: Drd4
Name: dopamine receptor D4
Description: Exhibits dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; behavioral response to cocaine; and inhibitory postsynaptic potential. Localizes to the glutamatergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and dyslexia. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human DRD4 (dopamine receptor D4); PARTICIPATES IN dopamine signaling pathway; dopamine signaling pathway via D2 family of receptors; excitatory synaptic transmission pathway; INTERACTS WITH 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one; 3',5'-cyclic AMP; arsenite(3-).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW125663; d(2C) dopamine receptor; D(4) dopamine receptor; D4R; dopamine D4 receptor; dopamine receptor 4; Drd-4
Orthologs:
Homo sapiens (human) : DRD4 (dopamine receptor D4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Drd4 (dopamine receptor D4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Drd4 (dopamine receptor D4)
Pan paniscus (bonobo/pygmy chimpanzee) : DRD4 (dopamine receptor D4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Drd4 (dopamine receptor D4)
Sus scrofa (pig) : DRD4 (dopamine receptor D4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm387141,291,974 - 141,296,464 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377148,477,905 - 148,480,900 (+)NCBIGRCm37mm9NCBIm37
MGSCv367141,143,326 - 141,146,321 (+)NCBImm8
Celera7141,085,754 - 141,088,749 (+)NCBICelera
Cytogenetic Map7 F5NCBI
cM Map786.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Drd4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10487
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.