Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dyrk1a (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a) Mus musculus
Symbol: Dyrk1a
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Description: Exhibits several functions, including identical protein binding activity; protein self-association; and tau protein binding activity. Involved in several processes, including negative regulation of mRNA splicing, via spliceosome; negative regulation of microtubule polymerization; and protein phosphorylation. Localizes to several cellular components, including the axon; cytoskeleton; and dendrite. Predicted to colocalize with the actin filament; microtubule; and neurofilament. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Down syndrome; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310043O08Rik; D16Ertd272e; D16Ertd493e; dual specificity tyrosine-phosphorylation-regulated kinase 1A; dual specificity YAK1-related kinase; Dyrk; ENSMUSG00000074897; Gm10783; MGC150253; MGC150254; mmb; Mnbh; Mp86; protein kinase minibrain homolog
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1694,570,010 - 94,695,517 (+)Ensembl
GRCm381694,569,947 - 94,695,519 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371694,791,813 - 94,917,126 (+)NCBIGRCm37mm9NCBIm37
MGSCv361694,720,258 - 94,801,189 (+)NCBImm8
Celera1695,699,096 - 95,783,175 (+)NCBICelera
Cytogenetic Map16 C4NCBI
cM Map1655.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dyrk1a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10495
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.