Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dyrk1a (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a) Mus musculus
Analyze
Symbol: Dyrk1a
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Description: Exhibits several functions, including identical protein binding activity; protein self-association; and tau protein binding activity. Involved in several processes, including negative regulation of mRNA splicing, via spliceosome; negative regulation of microtubule polymerization; and protein phosphorylation. Localizes to several cellular components, including the axon; cytoskeleton; and dendrite. Predicted to colocalize with the actin filament; microtubule; and neurofilament. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Down syndrome; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310043O08Rik; D16Ertd272e; D16Ertd493e; dual specificity tyrosine-phosphorylation-regulated kinase 1A; dual specificity YAK1-related kinase; Dyrk; ENSMUSG00000074897; Gm10783; MGC150253; MGC150254; mmb; Mnbh; Mp86; protein kinase minibrain homolog
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1694,570,010 - 94,695,517 (+)Ensembl
GRCm381694,569,947 - 94,695,519 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371694,791,813 - 94,917,126 (+)NCBIGRCm37mm9NCBIm37
MGSCv361694,720,258 - 94,801,189 (+)NCBImm8
Celera1695,699,096 - 95,783,175 (+)NCBICelera
Cytogenetic Map16 C4NCBI
cM Map1655.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dyrk1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10495
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.