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Gene: Ercc5 (excision repair cross-complementing rodent repair deficiency, complementation group 5) Mus musculus
Symbol: Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Description: Predicted to have several functions, including DNA binding activity; RNA polymerase II complex binding activity; and protein homodimerization activity. Involved in several processes, including UV protection; determination of adult lifespan; and growth. Predicted to colocalize with the DNA replication factor A complex. Used to study xeroderma pigmentosum group G. Human ortholog(s) of this gene implicated in melanoma and xeroderma pigmentosum group G. Is expressed in central nervous system and retina. Orthologous to human ERCC5 (ERCC excision repair 5, endonuclease); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells homolog; MGC176031; xeroderma pigmentosum group G-complementing protein homolog; xeroderma pigmentosum, complementation group G; Xpg
Homo sapiens (human) : ERCC5 (ERCC excision repair 5, endonuclease)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ercc5 (ERCC excision repair 5, endonuclease)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ercc5 (ERCC excision repair 5, endonuclease)
Pan paniscus (bonobo/pygmy chimpanzee) : ERCC5 (ERCC excision repair 5, endonuclease)
Canis lupus familiaris (dog) : ERCC5 (ERCC excision repair 5, endonuclease)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101968680 (DNA repair protein complementing XP-G cells)
Sus scrofa (pig) : ERCC5 (ERCC excision repair 5, endonuclease)
Chlorocebus sabaeus (African green monkey) : ERCC5 (ERCC excision repair 5, endonuclease)
Heterocephalus glaber (naked mole-rat) : Ercc5 (ERCC excision repair 5, endonuclease)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl144,147,744 - 44,181,260 (+)EnsemblGRCm38mm10GRCm38
GRCm38144,146,948 - 44,181,260 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37144,204,589 - 44,238,105 (+)NCBIGRCm37mm9NCBIm37
MGSCv36144,092,393 - 44,125,806 (+)NCBImm8
Celera144,491,664 - 44,523,751 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ercc5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10534
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.