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Gene: Gad2 (glutamic acid decarboxylase 2) Mus musculus
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Symbol: Gad2
Name: glutamic acid decarboxylase 2
Description: Predicted to have glutamate binding activity; glutamate decarboxylase activity; and pyridoxal phosphate binding activity. Predicted to be involved in glutamate decarboxylation to succinate. Localizes to axon; cytoplasm; and synapse. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study epilepsy and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Orthologous to human GAD2 (glutamate decarboxylase 2); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; beta-alanine metabolic pathway; butanoate metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6330404F12Rik; 65 kDa glutamic acid decarboxylase; GAD(65); Gad-2; GAD-65; GAD65; glutamate decarboxylase 2; glutamate decarboxylase 65 kDa isoform
Orthologs:
Homo sapiens (human) : GAD2 (glutamate decarboxylase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gad2 (glutamate decarboxylase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gad2 (glutamate decarboxylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GAD2 (glutamate decarboxylase 2)
Canis lupus familiaris (dog) : GAD2 (glutamate decarboxylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gad2 (glutamate decarboxylase 2)
Sus scrofa (pig) : GAD2 (glutamate decarboxylase 2)
Chlorocebus sabaeus (African green monkey) : GAD2 (glutamate decarboxylase 2)
Heterocephalus glaber (naked mole-rat) : Gad2 (glutamate decarboxylase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl222,622,205 - 22,693,874 (+)EnsemblGRCm38mm10GRCm38
GRCm38222,621,015 - 22,693,877 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37222,477,847 - 22,549,397 (+)NCBIGRCm37mm9NCBIm37
MGSCv36222,473,967 - 22,542,641 (+)NCBImm8
Celera222,352,193 - 22,424,544 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gad2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10616
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.