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Gene: Glo1 (glyoxalase 1) Mus musculus
Symbol: Glo1
Name: glyoxalase 1
CRRD ID: 10653
Description: Exhibits lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation and regulation of transcription by RNA polymerase II. Predicted to localize to cytosol; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I); PARTICIPATES IN glyoxalase metabolic pathway; Leigh disease pathway; primary hyperoxaluria type 2 pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0610009E22Rik; 1110008E19Rik; 2510049H23Rik; aldoketomutase; AW550643; Glo; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; glx I; GLY1; glyoxalase 1 complex; glyoxalase 1 regulatory; glyoxalase 1 structural; glyoxalase I; ketone-aldehyde mutase; lactoylglutathione lyase; methylglyoxalase; Qg; Qglo; S-D-lactoylglutathione methylglyoxal lyase
Homo sapiens (human) : GLO1 (glyoxalase I)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Glo1 (glyoxalase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glo1 (glyoxalase I)
Pan paniscus (bonobo/pygmy chimpanzee) : GLO1 (glyoxalase I)
Canis lupus familiaris (dog) : GLO1 (glyoxalase I)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glo1 (glyoxalase I)
Sus scrofa (pig) : GLO1 (glyoxalase I)
Chlorocebus sabaeus (African green monkey) : GLO1 (glyoxalase I)
Heterocephalus glaber (naked mole-rat) : Glo1 (glyoxalase I)
more info ...
Related Pseudogenes: Glo1-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391730,811,835 - 30,831,633 (-)NCBI
GRCm381730,592,861 - 30,612,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1730,584,936 - 30,626,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv371730,729,806 - 30,749,604 (-)NCBIGRCm37mm9NCBIm37
MGSCv361729,807,695 - 29,826,707 (-)NCBImm8
MGSCv361730,319,873 - 30,339,606 (-)NCBImm8
Celera235,035,059 - 35,036,311 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Glo1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10653
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.