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Gene: Glo1 (glyoxalase 1) Mus musculus
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Symbol: Glo1
Name: glyoxalase 1
CRRD ID: 10653
Description: Exhibits lactoylglutathione lyase activity and zinc ion binding activity. Involved in osteoclast differentiation and regulation of transcription by RNA polymerase II. Predicted to localize to cytosol; nucleoplasm; and plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I); PARTICIPATES IN glyoxalase metabolic pathway; Leigh disease pathway; primary hyperoxaluria type 2 pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 0610009E22Rik; 1110008E19Rik; 2510049H23Rik; aldoketomutase; AW550643; Glo; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; glx I; GLY1; glyoxalase 1 complex; glyoxalase 1 regulatory; glyoxalase 1 structural; glyoxalase I; ketone-aldehyde mutase; lactoylglutathione lyase; methylglyoxalase; Qg; Qglo; S-D-lactoylglutathione methylglyoxal lyase
Orthologs:
Homo sapiens (human) : GLO1 (glyoxalase I)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Glo1 (glyoxalase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glo1 (glyoxalase I)
Pan paniscus (bonobo/pygmy chimpanzee) : GLO1 (glyoxalase I)
Canis lupus familiaris (dog) : GLO1 (glyoxalase I)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glo1 (glyoxalase I)
Sus scrofa (pig) : GLO1 (glyoxalase I)
Chlorocebus sabaeus (African green monkey) : GLO1 (glyoxalase I)
Heterocephalus glaber (naked mole-rat) : Glo1 (glyoxalase I)
more info ...
Related Pseudogenes: Glo1-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391730,811,835 - 30,831,633 (-)NCBI
GRCm381730,592,861 - 30,612,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1730,584,936 - 30,626,871 (-)EnsemblGRCm38mm10GRCm38
MGSCv371730,729,806 - 30,749,604 (-)NCBIGRCm37mm9NCBIm37
MGSCv361729,807,695 - 29,826,707 (-)NCBImm8
MGSCv361730,319,873 - 30,339,606 (-)NCBImm8
Celera235,035,059 - 35,036,311 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Glo1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10653
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.