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Gene: Gpc3 (glypican 3) Mus musculus
Symbol: Gpc3
Name: glypican 3
Description: Predicted to have peptidyl-dipeptidase inhibitor activity. Involved in several processes, including animal organ development; positive regulation of transport; and regulation of signal transduction. Localizes to the anchored component of plasma membrane and lysosome. Used to study Simpson-Golabi-Behmel syndrome type 1. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Is expressed in several structures, including brain; branchial arch; future brain; reproductive system; and urinary system. Orthologous to human GPC3 (glypican 3); PARTICIPATES IN Hedgehog signaling pathway; glypican signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; cadmium sulfate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glypican-3; OCI-5
Homo sapiens (human) : GPC3 (glypican 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gpc3 (glypican 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpc3 (glypican 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GPC3 (glypican 3)
Canis lupus familiaris (dog) : GPC3 (glypican 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpc3 (glypican 3)
Sus scrofa (pig) : GPC3 (glypican 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38X52,272,426 - 52,613,974 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X49,625,603 - 49,967,151 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X48,517,053 - 48,858,548 (-)NCBImm8
CeleraX39,684,455 - 40,028,880 (-)NCBICelera
Cytogenetic MapX A5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gpc3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10677
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.