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Gene: Gpc3 (glypican 3) Mus musculus
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Symbol: Gpc3
Name: glypican 3
Description: Predicted to have peptidyl-dipeptidase inhibitor activity. Involved in several processes, including animal organ development; positive regulation of transport; and regulation of signal transduction. Localizes to the anchored component of plasma membrane and lysosome. Used to study Simpson-Golabi-Behmel syndrome type 1. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1; hepatocellular carcinoma; and nephroblastoma. Is expressed in several structures, including brain; branchial arch; future brain; reproductive system; and urinary system. Orthologous to human GPC3 (glypican 3); PARTICIPATES IN Hedgehog signaling pathway; glypican signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; cadmium sulfate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glypican-3; OCI-5
Orthologs:
Homo sapiens (human) : GPC3 (glypican 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gpc3 (glypican 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpc3 (glypican 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GPC3 (glypican 3)
Canis lupus familiaris (dog) : GPC3 (glypican 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpc3 (glypican 3)
Sus scrofa (pig) : GPC3 (glypican 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38X52,272,426 - 52,613,974 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X49,625,603 - 49,967,151 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X48,517,053 - 48,858,548 (-)NCBImm8
CeleraX39,684,455 - 40,028,880 (-)NCBICelera
Cytogenetic MapX A5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Gpc3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10677
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.