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Gene: Grin1 (glutamate receptor, ionotropic, NMDA1 (zeta 1)) Mus musculus
Symbol: Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Description: Exhibits several functions, including calmodulin binding activity; cation binding activity; and ion channel activity. Involved in several processes, including chemical synaptic transmission; learning or memory; and nervous system development. Localizes to several cellular components, including glutamatergic synapse; integral component of plasma membrane; and synaptic vesicle membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder and schizophrenia. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GluN1; GluRdelta1; GluRzeta1; glutamate [NMDA] receptor subunit zeta-1; glutamate receptor ionotropic, NMDA 1; M100174; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; Nmdar; NMDAR1; NR1; Rgsc174
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl225,291,181 - 25,319,187 (-)EnsemblGRCm38mm10GRCm38
GRCm38225,291,177 - 25,319,187 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37225,146,697 - 25,174,683 (-)NCBIGRCm37mm9NCBIm37
MGSCv36225,114,256 - 25,140,988 (-)NCBImm8
Celera225,018,687 - 25,046,664 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Grin1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10685
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.