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Gene: Grin2b (glutamate receptor, ionotropic, NMDA2B (epsilon 2)) Mus musculus
Symbol: Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Description: Exhibits NMDA glutamate receptor activity; calcium channel activity; and neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including behavioral fear response; detection of mechanical stimulus involved in sensory perception of pain; and learning or memory. Localizes to several cellular components, including NMDA selective glutamate receptor complex; cytoplasmic vesicle; and synaptic membrane. Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant non-syndromic intellectual disability 6; bipolar disorder; early infantile epileptic encephalopathy 27; and neurodegenerative disease (multiple). Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW490526; expressed sequence AW490526; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor ionotropic, NMDA 2B; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; Nmdar2b; NR2B
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl6135,713,233 - 136,173,511 (-)EnsemblGRCm38mm10GRCm38
GRCm386135,713,221 - 136,173,615 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376135,679,813 - 136,123,529 (-)NCBIGRCm37mm9NCBIm37
MGSCv366135,697,791 - 136,009,994 (-)NCBImm8
Celera6138,678,301 - 139,123,902 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Grin2b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10687
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.