Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Hk1 (hexokinase 1) Mus musculus
Symbol: Hk1
Name: hexokinase 1
CRRD ID: 10710
Description: Exhibits glucokinase activity and peptidoglycan binding activity. Involved in carbohydrate phosphorylation; positive regulation of cytokine production involved in immune response; and positive regulation of interleukin-1 beta production. Localizes to several cellular components, including membrane raft; mitochondrion; and sperm principal piece. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; fructose and mannose metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BB404130; dea; downeast anemia; hexokinase type I; hexokinase, tumor isozyme; hexokinase-1; HK I; Hk-1; Hk1-; Hk1-s; mHk1-; mHk1-s
Homo sapiens (human) : HK1 (hexokinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hk1 (hexokinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hk1 (hexokinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HK1 (hexokinase 1)
Canis lupus familiaris (dog) : HK1 (hexokinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hk1 (hexokinase 1)
Sus scrofa (pig) : HK1 (hexokinase 1)
Chlorocebus sabaeus (African green monkey) : HK1 (hexokinase 1)
Heterocephalus glaber (naked mole-rat) : Hk1 (hexokinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391062,104,634 - 62,215,699 (-)NCBI
GRCm381062,268,855 - 62,379,920 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,268,855 - 62,379,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv371061,731,603 - 61,842,656 (-)NCBIGRCm37mm9NCBIm37
MGSCv361061,665,219 - 61,775,240 (-)NCBImm8
Celera1063,372,104 - 63,483,135 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hk1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10710
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.