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Gene: Onecut1 (one cut domain, family member 1) Mus musculus
Symbol: Onecut1
Name: one cut domain, family member 1
CRRD ID: 10721
Description: Exhibits DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including Notch signaling pathway; animal organ development; and negative regulation of transforming growth factor beta receptor signaling pathway. Localizes to nucleus. Is expressed in several structures, including central nervous system; gut; liver and biliary system; retina; and urinary system. Orthologous to human ONECUT1 (one cut homeobox 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
Also known as: D9Ertd423; D9Ertd423e; hepatic nuclear factor 6; hepatocyte nuclear factor 6; Hfh12; HNF; HNF-3/forkhead homolog 12; HNF-6; Hnf6; Hnf6b; Oc; OC-; OC-1; Oc1; one cut domain family member 1; one cut homeobox 1
Homo sapiens (human) : ONECUT1 (one cut homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Onecut1 (one cut homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Onecut1 (one cut homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ONECUT1 (one cut homeobox 1)
Canis lupus familiaris (dog) : ONECUT1 (one cut homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Onecut1 (one cut homeobox 1)
Sus scrofa (pig) : ONECUT1 (one cut homeobox 1)
Chlorocebus sabaeus (African green monkey) : ONECUT1 (one cut homeobox 1)
Heterocephalus glaber (naked mole-rat) : Onecut1 (one cut homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39974,769,203 - 74,796,930 (+)NCBI
GRCm38974,861,921 - 74,889,648 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl974,861,921 - 74,891,781 (+)EnsemblGRCm38mm10GRCm38
MGSCv37974,709,728 - 74,737,455 (+)NCBIGRCm37mm9NCBIm37
MGSCv36974,648,524 - 74,676,252 (+)NCBImm8
Celera972,045,890 - 72,046,250 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map941.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Onecut1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10721
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.