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Gene: Hspa8 (heat shock protein 8) Mus musculus
Symbol: Hspa8
Name: heat shock protein 8
Description: Exhibits ATPase activity, coupled; phosphatidylserine binding activity; and unfolded protein binding activity. Involved in several processes, including chaperone cofactor-dependent protein refolding; late endosomal microautophagy; and positive regulation by host of viral genome replication. Localizes to several cellular components, including extracellular exosome; glycinergic synapse; and photoreceptor ribbon synapse. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; brain; eye; and liver. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8); PARTICIPATES IN androgen signaling pathway; chaperone mediated autophagy pathway; clathrin-dependent synaptic vesicle endocytosis; INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; (S)-amphetamine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2410008N15Rik; heat shock 70 kDa protein 8; heat shock 70kD protein 8; heat shock cognate 71 kDa protein; heat shock cognate hsc73; heat shock protein cognate 70; Hsc70; Hsc71; Hsc73; Hsp73; Hspa10; MGC102007; MGC106514; MGC118485
Homo sapiens (human) : HSPA8 (heat shock protein family A (Hsp70) member 8)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspa8 (heat shock protein family A (Hsp70) member 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspa8 (heat shock protein family A (Hsp70) member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Canis lupus familiaris (dog) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa8 (heat shock protein family A (Hsp70) member 8)
Sus scrofa (pig) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Chlorocebus sabaeus (African green monkey) : HSPA8 (heat shock protein family A (Hsp70) member 8)
Heterocephalus glaber (naked mole-rat) : Hspa8 (heat shock protein family A (Hsp70) member 8)
more info ...
Related Pseudogenes: Gm13854   Gm15459   Gm15604   Gm17976   Gm18069   Gm5575   Gm6210   Gm7048   Gm7232   Gm7899   Gm8141   Gm8326   Gm8337   Gm8355   Gm9436  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl940,800,984 - 40,810,087 (+)EnsemblGRCm38mm10GRCm38
GRCm38940,801,276 - 40,805,202 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37940,609,356 - 40,613,282 (+)NCBIGRCm37mm9NCBIm37
MGSCv3658,102,053 - 8,104,168 (+)NCBImm8
MGSCv36940,552,355 - 40,556,269 (+)NCBImm8
Celera938,034,609 - 38,038,251 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map921.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hspa8
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10733
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.