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Gene: Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2) Mus musculus
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
CRRD ID: 10735
Description: Predicted to have 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; NAD binding activity; and steroid binding activity. Involved in female pregnancy. Predicted to localize to cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; ear; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 11(beta)-HSD2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11HSD; 11HSD2; corticosteroid 11-beta-dehydrogenase isozyme 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Homo sapiens (human) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Canis lupus familiaris (dog) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
Sus scrofa (pig) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Chlorocebus sabaeus (African green monkey) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Heterocephalus glaber (naked mole-rat) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm398106,245,378 - 106,250,620 (+)NCBI
GRCm388105,518,746 - 105,523,988 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,518,755 - 105,523,988 (+)EnsemblGRCm38mm10GRCm38
MGSCv378108,042,646 - 108,047,888 (+)NCBIGRCm37mm9NCBIm37
MGSCv368108,407,983 - 108,412,647 (+)NCBImm8
Celera8109,741,823 - 109,747,238 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hsd11b2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10735
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.