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Gene: Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2) Mus musculus
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Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Description: Predicted to have 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; NAD binding activity; and steroid binding activity. Involved in female pregnancy. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Is expressed in several structures, including adrenal gland; ear; genitourinary system; hemolymphoid system; and nervous system. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 11(beta)-HSD2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11HSD2; corticosteroid 11-beta-dehydrogenase isozyme 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Orthologs:
Homo sapiens (human) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Canis lupus familiaris (dog) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hsd11b2 (hydroxysteroid 11-beta dehydrogenase 2)
Sus scrofa (pig) : HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm388105,518,746 - 105,523,988 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378108,042,646 - 108,047,888 (+)NCBIGRCm37mm9NCBIm37
MGSCv368108,407,983 - 108,412,647 (+)NCBImm8
Celera8109,741,823 - 109,747,238 (+)NCBICelera
Cytogenetic Map8 D3NCBI
cM Map853.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hsd11b2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10735
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.