Gene: Htr1d (5-hydroxytryptamine (serotonin) receptor 1D) Mus musculus
Analyze
Symbol:
Htr1d
Name:
5-hydroxytryptamine (serotonin) receptor 1D
Description:
Exhibits G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in response to toxic substance. Predicted to localize to the dendrite and integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Orthologous to human HTR1D (5-hydroxytryptamine receptor 1D); INTERACTS WITH bisphenol A; capsaicin; dextran sulfate.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
5-HT-1D; 5-HT1D; 5-hydroxytryptamine (serotonin) receptor 1D beta; 5-hydroxytryptamine receptor 1D; AI853647; G-protein coupled receptor 14; Gpcr14; Htr1db; serotonin receptor 1D
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
HTR1D (5-hydroxytryptamine receptor 1D) HGNC
Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Rattus norvegicus (Norway rat):
Htr1d (5-hydroxytryptamine receptor 1D) HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Htr1d (5-hydroxytryptamine receptor 1D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
HTR1D (5-hydroxytryptamine receptor 1D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
HTR1D (5-hydroxytryptamine receptor 1D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Htr1d (5-hydroxytryptamine receptor 1D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HTR1D (5-hydroxytryptamine receptor 1D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Htr1d (5-hydroxytryptamine receptor 1D)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
HTR1D (5-hydroxytryptamine receptor 1D)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
htr1d (5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
ser-4
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
5-HT1B
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
5-HT7
Alliance
DIOPT (OrthoInspector, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 4 136,423,522 - 136,444,405 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 4 135,979,439 - 136,000,317 (+) NCBI GRCm37 mm9 NCBIm37 MGSCv36 4 135,695,600 - 135,716,474 (+) NCBI mm8 Celera 4 134,616,431 - 134,638,377 (+) NCBI Celera Cytogenetic Map 4 D3 NCBI cM Map 4 68.74 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:736440 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HTR1D mRNA CTD PMID:22079256 6-propyl-2-thiouracil decreases expression ISO RGD:2847 6480464 Propylthiouracil results in decreased expression of HTR1D mRNA CTD PMID:24780913 amitriptyline decreases expression ISO RGD:2847 6480464 Amitriptyline results in decreased expression of HTR1D mRNA CTD PMID:22341215 ammonium chloride affects expression ISO RGD:2847 6480464 Ammonium Chloride affects the expression of HTR1D mRNA CTD PMID:16483693 arsenous acid decreases response to substance ISO RGD:736440 6480464 HTR1D protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 benzo[a]pyrene increases mutagenesis ISO RGD:736440 6480464 Benzo(a)pyrene results in increased mutagenesis of HTR1D gene CTD PMID:25435355 benzo[a]pyrene decreases expression ISO RGD:2847 6480464 Benzo(a)pyrene results in decreased expression of HTR1D mRNA CTD PMID:21839799 bisphenol A decreases expression ISO RGD:2847 6480464 bisphenol A results in decreased expression of HTR1D mRNA CTD PMID:25181051 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of HTR1D promoter CTD PMID:27312807 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of HTR1D promoter CTD PMID:27312807 bisphenol A increases methylation ISO RGD:2847 6480464 bisphenol A results in increased methylation of HTR1D gene CTD PMID:28505145 bisphenol F decreases expression ISO RGD:2847 6480464 4, 4'-bisphenol F results in decreased expression of HTR1D mRNA CTD PMID:26186136 butanal decreases expression ISO RGD:736440 6480464 butyraldehyde results in decreased expression of HTR1D mRNA CTD PMID:26079696 capsaicin multiple interactions EXP 6480464 HTR1D protein inhibits the reaction [Capsaicin results in increased expression of FOS protein] CTD PMID:12110114 carbon nanotube decreases expression ISO RGD:736440 6480464 Nanotubes, Carbon analog results in decreased expression of HTR1D mRNA CTD PMID:25102311 chlorpyrifos increases expression ISO RGD:2847 6480464 Chlorpyrifos results in increased expression of HTR1D mRNA CTD PMID:18835401 clozapine decreases expression ISO RGD:2847 6480464 Clozapine results in decreased expression of HTR1D mRNA CTD PMID:16715494 cocaine affects expression ISO RGD:2847 6480464 Cocaine affects the expression of HTR1D mRNA CTD PMID:20187946 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of HTR1D mRNA CTD PMID:29950665 diarsenic trioxide decreases response to substance ISO RGD:736440 6480464 HTR1D protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 diazinon decreases expression ISO RGD:2847 6480464 Diazinon results in decreased expression of HTR1D mRNA CTD PMID:18835401 dieldrin affects expression ISO RGD:2847 6480464 Dieldrin affects the expression of HTR1D mRNA CTD PMID:18835401 eletriptan multiple interactions ISO RGD:2847 6480464 eletriptan binds to and results in increased activity of HTR1D protein CTD PMID:11301495 ethanol increases expression ISO RGD:736440 6480464 Ethanol results in increased expression of HTR1D mRNA CTD PMID:23378141 ethanol multiple interactions ISO RGD:736440 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of HTR1D mRNA CTD PMID:23378141 folic acid multiple interactions ISO RGD:736440 6480464 [Ethanol co-treated with Folic Acid] results in increased expression of HTR1D mRNA CTD PMID:23378141 gentamycin decreases expression ISO RGD:2847 6480464 Gentamicins results in decreased expression of HTR1D mRNA CTD PMID:22061828 haloperidol decreases expression ISO RGD:2847 6480464 Haloperidol results in decreased expression of HTR1D mRNA CTD PMID:16715494 lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of HTR1D mRNA CTD PMID:22613225 naratriptan affects binding ISO RGD:736440 6480464 naratriptan binds to HTR1D protein CTD PMID:9170336 nickel atom affects expression ISO RGD:2847 6480464 Nickel affects the expression of HTR1D mRNA CTD PMID:18835401 nickel sulfate increases expression ISO RGD:736440 6480464 nickel sulfate results in increased expression of HTR1D mRNA CTD PMID:22714537 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of HTR1D mRNA CTD PMID:17562736 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of HTR1D mRNA CTD PMID:17950772 potassium chromate decreases expression ISO RGD:736440 6480464 potassium chromate(VI) results in decreased expression of HTR1D mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:736440 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HTR1D mRNA CTD PMID:22079256 serotonin affects abundance ISO RGD:736440 6480464 HTR1D gene polymorphism affects the abundance of Serotonin CTD PMID:17203304 sumatriptan multiple interactions ISO RGD:2847 6480464 Sumatriptan binds to and results in increased activity of HTR1D protein CTD PMID:11301495 tamoxifen increases expression EXP 6480464 Tamoxifen results in increased expression of HTR1D mRNA CTD PMID:25123088 tetrachloromethane increases expression ISO RGD:736440 6480464 Carbon Tetrachloride results in increased expression of HTR1D mRNA CTD PMID:11566570 tetrachloromethane increases expression ISO RGD:2847 6480464 Carbon Tetrachloride results in increased expression of HTR1D mRNA CTD PMID:16644059 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of HTR1D mRNA CTD PMID:29950665
Gene Ontology Annotations
Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO UniProtKB:P28221 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 chemical synaptic transmission IBA PANTHER:PTN000664111 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 G protein-coupled receptor signaling pathway IEA UniProtKB-KW:KW-0297 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 G protein-coupled receptor signaling pathway IEA InterPro:IPR000276 more ... 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA PANTHER:PTN000664111 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 intestine smooth muscle contraction ISO UniProtKB:P28221 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 regulation of behavior IEA InterPro:IPR000505 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 regulation of locomotion IEA InterPro:IPR000505 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 response to toxic substance IDA 2290270 (MGI:MGI:48584, PMID:1557407) MGI MGI:MGI:48584 , PMID:1557407 signal transduction IEA UniProtKB-KW:KW-0807 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 smooth muscle contraction IEA InterPro:IPR000505 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 vasoconstriction IEA InterPro:IPR000505 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 Cellular Component dendrite IBA PANTHER:PTN000664111 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 integral component of membrane IEA UniProtKB-KW:KW-0812 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 integral component of membrane IEA InterPro:IPR000276 , InterPro:IPR017452 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098 integral component of plasma membrane ISO UniProtKB:P28221 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 integral component of plasma membrane IBA FB:FBgn0000037 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 membrane IEA UniProtKB-KW:KW-0472 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 plasma membrane IEA UniProtKB-KW:KW-1003 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 Molecular Function G protein-coupled receptor activity IBA PANTHER:PTN000664111 , RGD:2518 2290270 (PMID:21873635) GO_Central PMID:21873635 G protein-coupled serotonin receptor activity IDA 2290270 (MGI:MGI:48584, PMID:1557407) MGI MGI:MGI:48584 , PMID:1557407 G protein-coupled serotonin receptor activity IBA FB:FBgn0004168 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 G protein-coupled serotonin receptor activity ISO UniProtKB:P28221 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 neurotransmitter receptor activity IBA PANTHER:PTN000664111 , RGD:71034 2290270 (PMID:21873635) GO_Central PMID:21873635 serotonin binding IDA 2290270 (MGI:MGI:48584, PMID:1557407) MGI MGI:MGI:48584 , PMID:1557407
Phenotype Annotations
11567249 Elorr3_m ethanol induced loss of righting response 3 (mouse) 4 3722677 156183778 Mouse 1357895 Ctrcts_m cataract severity (mouse) Not determined 4 45709925 138615442 Mouse 4141549 W10q10_m weight 10 weeks QTL 10 (mouse) Not determined 89063832 140740892 Mouse 4141093 W3q17_m weight 3 weeks QTL 17 (mouse) Not determined 89063832 140740892 Mouse 4141623 W6q13_m weight 6 weeks QTL 13 (mouse) Not determined 89063832 140740892 Mouse 1357529 Lvrq8_m liver weight QTL 8 (mouse) Not determined 4 89063832 140740892 Mouse 1301823 Bmd7_m bone mineral density 7 (mouse) Not determined 4 89063832 151570093 Mouse 13208562 Wght7_m weight 7 (mouse) 4 91000000 148000000 Mouse 1301815 Sles2_m systemic lupus erythmatosus suppressor 2 (mouse) Not determined 4 95069342 150592401 Mouse 15039377 Bw45_m body weight QTL 45 (mouse) 4 105812001 139812001 Mouse 15039378 Adip30_m adiposity 30 (mouse) 4 105812001 139812001 Mouse 15039382 Ltgq7_m liver triglyceride QTL 7 (mouse) 4 105812001 139812001 Mouse 12910794 Pwbwq8_m post-weaning body weight QTL 8 (mouse) 4 105978113 141706527 Mouse 12910797 Pwgrq4_m pre-weaning growth rate QTL 4 (mouse) 4 105978113 141706527 Mouse 12910808 Pwbwq9_m post-weaning body weight QTL 9 (mouse) 4 105978113 141706527 Mouse 12910813 Pwbwq4_m pre-weaning body weight QTL 4 (mouse) 4 105978113 141706527 Mouse 1357800 Tgq3_m triglyceride QTL 3 (mouse) Not determined 4 107161300 141161387 Mouse 1300663 Start2_m startle response 2 (mouse) Not determined 4 107371164 141371360 Mouse 1300809 Ccrs2_m corpus callosum hemisphere surface size 2 (mouse) Not determined 4 107371164 141371360 Mouse 1300781 Lith8_m lithogenic gene 8 (mouse) Not determined 4 107371164 141371360 Mouse 1301382 Arvm2_m autoimmune renal vasculitis 2 (mouse) Not determined 4 107897771 141897963 Mouse 10755520 Rbc1_m red blood cell count 1 (mouse) 4 108583899 142583899 Mouse 10755522 Hgb1_m hemoglobin 1 (mouse) 4 108583899 142583899 Mouse 10755521 Hct1_m hematocrit 1 (mouse) 4 108583899 142583899 Mouse 1300839 Dyscalc2_m dystrophic cardiac calcinosis 2 (mouse) Not determined 4 111115258 145115487 Mouse 1300743 Skull6_m skull morphology 6 (mouse) Not determined 4 111115258 145115487 Mouse 15039385 Mvlq3_m macrovesicular liver lesion QTL 3 (mouse) 4 112288593 146288593 Mouse 4141001 Tgq17_m triglyceride QTL 17 (mouse) Not determined 112629696 146629696 Mouse 10047132 Albq19_m albuminuria QTL 19 (mouse) Not determined 4 112930596 146930596 Mouse 4142493 Femwf13_m femur work to failure 13 (mouse) Not determined 116427367 150427471 Mouse 1302078 Sluc21_m susceptibility to lung cancer 21 (mouse) Not determined 4 117673830 151673964 Mouse 14746982 Manh56_m mandible shape 56 (mouse) 4 118088606 152088606 Mouse 1301964 Bw8q2_m body weight at 8 weeks QTL 2 (mouse) Not determined 4 120137122 154137225 Mouse 1302102 Bis1_m beta-carboline-induced seizures 1 (mouse) Not determined 4 120137122 154137225 Mouse 13503348 Bntq18_m bone traits QTL 18 (mouse) 4 120890537 154890684 Mouse 10412210 Cypr6_m cytokine production 6 (mouse) Not determined 4 120890537 154890684 Mouse 1300803 Sluc6_m susceptibility to lung cancer 6 (mouse) Not determined 4 120946694 154946840 Mouse 4141180 Ssic1_m susceptibility to small intestinal cancer 1 (mouse) Not determined 120946694 154946840 Mouse 4142061 Chlq16_m circulating hormone level QTL 16 (mouse) Not determined 4 121615338 155615442 Mouse 1301452 Elsgp1_m elevated serum gp70 1 (mouse) Not determined 4 121615338 155615442 Mouse 10043985 Stheal12_m soft tissue heal 12 (mouse) Not determined 4 121615338 155615442 Mouse 4141065 Shali2_m survival time to hyperoxic acute lung injury 2 (mouse) Not determined 124161300 141845481 Mouse 1300917 Gasa1_m gastritis type A susceptibility locus 1 (mouse) Not determined 4 124161300 142711450 Mouse 1302149 Tlsr2_m thymic lymphoma suppressor region 2 (mouse) Not determined 4 124371164 142504390 Mouse 1301525 Lmb1_m lupus in MRL and B6 F2 cross (mouse) Not determined 4 124371164 150592401 Mouse 10755531 Lymph3_m lymphocyte differential 3 (mouse) 4 124826172 156508116 Mouse 1301982 Pltiq1_m phospholipid transfer protein inducibility QTL 1 (mouse) Not determined 4 124893970 156508116 Mouse 1300858 Tafat_m tally ho associated mesenteric fat pad weight (mouse) Not determined 4 124893970 156508116 Mouse 4142139 Adip12_m adiposity 12 (mouse) Not determined 4 124893970 156508116 Mouse 1300933 Cdcs9_m cytokine deficiency colitis susceptibility 9 (mouse) Not determined 4 125504302 156508116 Mouse 10045620 Heal22_m wound healing/regeneration 22 (mouse) Not determined 4 125504302 156508116 Mouse 1300621 Tpnr1_m thermal pain response 1 (mouse) Not determined 4 125504302 156508116 Mouse 11533916 Mts1_m mammary tumor susceptibility 1 (mouse) 4 125562755 156508116 Mouse 4142481 Gct1_m granulosa cell tumorigenesis 1 (mouse) Not determined 4 128057656 156508116 Mouse 10043996 Gct5_m granulosa cell tumorigenesis 5 (mouse) Not determined 4 128057656 156508116 Mouse 1301793 Tlsr3_m thymic lymphoma suppressor region 3 (mouse) Not determined 4 129572018 137137225 Mouse 1301584 Lrdg2_m light induced retinal degeneration 2 (mouse) Not determined 4 129572018 151570093 Mouse 4141154 Nba1_m New Zealand Black autoimmunity 1 (mouse) Not determined 131923413 141151964 Mouse 1300874 Gasa2_m gastritis type A susceptibility locus 2 (mouse) Not determined 4 132926037 156508116 Mouse 4142082 Psds2_m psoriasis-like skin disease severity 2 (mouse) Not determined 4 133427367 137890684 Mouse 1301267 Bcmd2_m B cell maturation defect 2 (mouse) Not determined 4 133427367 150704994 Mouse 4142077 Ignpq2_m IgA nephropathy QTL 2 (mouse) Not determined 4 133592276 156508116 Mouse 1301108 Scon2_m sucrose consumption 2 (mouse) Not determined 4 134569994 156508116 Mouse 1300537 Ap3q_m alcohol preference 3 QTL (mouse) Not determined 4 134569994 156508116 Mouse
Predicted Target Of
Count of predictions: 508 Count of miRNA genes: 300 Interacting mature miRNAs: 321 Transcripts: ENSMUST00000088677, ENSMUST00000117699, ENSMUST00000121571, ENSMUST00000133818 Prediction methods: Miranda, Rnahybrid Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
