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Gene: Idh1 (isocitrate dehydrogenase 1 (NADP+), soluble) Mus musculus
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Symbol: Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
Description: Exhibits isocitrate dehydrogenase (NADP+) activity. Involved in glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Localizes to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in acute myeloid leukemia; glioblastoma multiforme; hepatocellular clear cell carcinoma; malignant glioma; and myelodysplastic syndrome. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1); PARTICIPATES IN citric acid cycle pathway; glutathione metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI314845; AI788952; cytosolic NADP-isocitrate dehydrogenase; E030024J03Rik; Id-1; IDH; Idh-1; IDP; Idpc; isocitrate dehydrogenase [NADP] cytoplasmic; MGC115782; NADP(+)-specific ICDH; oxalosuccinate decarboxylase
Orthologs:
Homo sapiens (human) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Canis lupus familiaris (dog) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
Sus scrofa (pig) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Chlorocebus sabaeus (African green monkey) : IDH1 (isocitrate dehydrogenase (NADP(+)) 1)
Heterocephalus glaber (naked mole-rat) : Idh1 (isocitrate dehydrogenase (NADP(+)) 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl165,158,616 - 65,186,500 (-)EnsemblGRCm38mm10GRCm38
GRCm38165,158,616 - 65,186,479 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37165,205,190 - 65,233,053 (-)NCBIGRCm37mm9NCBIm37
MGSCv36165,092,904 - 65,113,390 (-)NCBImm8
Celera165,649,214 - 65,677,085 (-)NCBICelera
Cytogenetic Map1C2NCBI
cM Map132.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Idh1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10758
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.