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Gene: Igfbp3 (insulin-like growth factor binding protein 3) Mus musculus
Symbol: Igfbp3
Name: insulin-like growth factor binding protein 3
Description: Exhibits fibronectin binding activity and insulin-like growth factor binding activity. Involved in several processes, including osteoblast differentiation; positive regulation of signal transduction; and type B pancreatic cell proliferation. Localizes to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Is expressed in several structures, including alimentary system; brain; early embryo; gonad; and immune system. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3); PARTICIPATES IN insulin-like growth factor signaling pathway; p53 signaling pathway; INTERACTS WITH 1,2-dichloroethane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI649005; IBP-3; IGF-binding protein 3; IGFBP-3; IGgfbp3; insulin-like growth factor-binding protein 3
Homo sapiens (human) : IGFBP3 (insulin like growth factor binding protein 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Igfbp3 (insulin-like growth factor binding protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igfbp3 (insulin like growth factor binding protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IGFBP3 (insulin like growth factor binding protein 3)
Canis lupus familiaris (dog) : IGFBP3 (insulin like growth factor binding protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igfbp3 (insulin like growth factor binding protein 3)
Sus scrofa (pig) : IGFBP3 (insulin like growth factor binding protein 3)
Chlorocebus sabaeus (African green monkey) : IGFBP3 (insulin like growth factor binding protein 3)
Heterocephalus glaber (naked mole-rat) : Igfbp3 (insulin like growth factor binding protein 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl117,206,086 - 7,213,923 (-)EnsemblGRCm38mm10GRCm38
GRCm38117,206,086 - 7,215,498 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37117,106,089 - 7,113,926 (-)NCBIGRCm37mm9NCBIm37
MGSCv36117,108,384 - 7,113,834 (-)NCBImm8
Celera117,681,286 - 7,689,161 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Igfbp3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10774
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.