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Gene: Ins2 (insulin II) Mus musculus
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Symbol: Ins2
Name: insulin II
Description: Predicted to have identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of phosphorylation. Localizes to several cellular components, including the cytosol; secretory granule; and small nucleolar ribonucleoprotein complex. Used to study maturity-onset diabetes of the young; permanent neonatal diabetes mellitus; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Is expressed in several structures, including brain; extraembryonic component; gut; immune system; and testis. Orthologous to several human genes including INS (insulin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AA986540; Ins-2; InsII; insulin-2; Mody; Mody4; proinsulin
Orthologs:
Homo sapiens (human) : INS (insulin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ins2 (insulin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ins (insulin)
Pan paniscus (bonobo/pygmy chimpanzee) : INS (insulin)
Canis lupus familiaris (dog) : INS (insulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ins (insulin)
Sus scrofa (pig) : INS (insulin)
Chlorocebus sabaeus (green monkey) : INS (insulin)
Heterocephalus glaber (naked mole-rat) : Ins (insulin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl7142,678,656 - 142,743,381 (-)Ensembl
GRCm387142,678,656 - 142,679,726 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377149,864,561 - 149,865,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,488,051 - 142,489,098 (-)NCBImm8
Celera7142,434,985 - 142,436,037 (-)NCBICelera
Cytogenetic Map7 F5NCBI
cM Map788.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ins2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10812
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.