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Gene: Irf1 (interferon regulatory factor 1) Mus musculus
Symbol: Irf1
Name: interferon regulatory factor 1
Description: Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including defense response to other organism; regulation of T cell activation; and regulation of gene expression. Localizes to cytoplasm and nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human IRF1 (interferon regulatory factor 1); PARTICIPATES IN interleukin-6 signaling pathway; Jak-Stat signaling pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-alpha-viniferin; 15-deoxy-Delta(12,14)-prostaglandin J2; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU020929; Irf-1
Homo sapiens (human) : IRF1 (interferon regulatory factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Irf1 (interferon regulatory factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irf1 (interferon regulatory factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRF1 (interferon regulatory factor 1)
Canis lupus familiaris (dog) : IRF1 (interferon regulatory factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irf1 (interferon regulatory factor 1)
Sus scrofa (pig) : IRF1 (interferon regulatory factor 1)
Chlorocebus sabaeus (African green monkey) : IRF1 (interferon regulatory factor 1)
Heterocephalus glaber (naked mole-rat) : Irf1 (interferon regulatory factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1153,770,014 - 53,778,374 (+)EnsemblGRCm38mm10GRCm38
GRCm381153,770,014 - 53,778,374 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371153,583,516 - 53,591,876 (+)NCBIGRCm37mm9NCBIm37
MGSCv361153,613,501 - 53,620,746 (+)NCBImm8
Celera1158,349,840 - 58,358,199 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Irf1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10815
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.