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Gene: Irs1 (insulin receptor substrate 1) Mus musculus
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Symbol: Irs1
Name: insulin receptor substrate 1
Description: Exhibits phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in several processes, including cellular response to insulin stimulus; positive regulation of phosphatidylinositol 3-kinase activity; and protein kinase B signaling. Localizes to several cellular components, including ciliary basal body; nucleus; and plasma membrane. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human IRS1 (insulin receptor substrate 1); PARTICIPATES IN leptin system pathway; insulin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ENSMUSG00000022591; G972R; IRS-1; predicted gene, ENSMUSG00000022591
Orthologs:
Homo sapiens (human) : IRS1 (insulin receptor substrate 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Irs1 (insulin receptor substrate 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irs1 (insulin receptor substrate 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRS1 (insulin receptor substrate 1)
Canis lupus familiaris (dog) : IRS1 (insulin receptor substrate 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irs1 (insulin receptor substrate 1)
Sus scrofa (pig) : IRS1 (insulin receptor substrate 1)
Chlorocebus sabaeus (African green monkey) : IRS1 (insulin receptor substrate 1)
Heterocephalus glaber (naked mole-rat) : Irs1 (insulin receptor substrate 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl182,233,101 - 82,291,416 (-)EnsemblGRCm38mm10GRCm38
GRCm38 Ensembl182,233,112 - 82,235,933 (+)EnsemblGRCm38mm10GRCm38
GRCm38182,233,105 - 82,291,439 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37182,229,680 - 82,288,014 (-)NCBIGRCm37mm9NCBIm37
MGSCv36182,115,634 - 82,170,440 (-)NCBImm8
Celera182,301,640 - 82,360,019 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map142.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Irs1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10816
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.