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Gene: Itpa (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)) Mus musculus
Symbol: Itpa
Name: inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Description: Exhibits dITP diphosphatase activity. Involved in ITP catabolic process and chromosome organization. Predicted to localize to the cytosol and nuclear body. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); early infantile epileptic encephalopathy 35; hepatitis C; precursor lymphoblastic lymphoma/leukemia; and rheumatoid arthritis. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ITPA (inosine triphosphatase); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; Benzo[ghi]perylene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2010016I08Rik; AU020102; inosine triphosphate pyrophosphatase; Itp; ITPase; non-canonical purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase; NTPase; nucleoside triphosphate pyrophosphatase; nucleoside-triphosphate diphosphatase; nucleoside-triphosphate pyrophosphatase
Homo sapiens (human) : ITPA (inosine triphosphatase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itpa (inosine triphosphatase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpa (inosine triphosphatase)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPA (inosine triphosphatase)
Canis lupus familiaris (dog) : ITPA (inosine triphosphatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpa (inosine triphosphatase)
Sus scrofa (pig) : ITPA (inosine triphosphatase)
more info ...
Related Pseudogenes: Itpa-ps1   Itpa-ps2   Itpa-ps3  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382130,664,692 - 130,681,614 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372130,493,577 - 130,507,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv362130,359,282 - 130,373,055 (+)NCBImm8
Celera2131,892,647 - 131,906,412 (+)NCBICelera
Cytogenetic Map2 F1NCBI
cM Map263.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Itpa
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10820
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.