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Gene: Kdr (kinase insert domain protein receptor) Mus musculus
Symbol: Kdr
Name: kinase insert domain protein receptor
Description: Exhibits growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of vasculature development. Localizes to several cellular components, including the cell junction; endosome; and external side of plasma membrane. Human ortholog(s) of this gene implicated in artery disease (multiple); macular degeneration (multiple); pancreatic cancer; and urinary bladder cancer. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Orthologous to human KDR (kinase insert domain receptor); PARTICIPATES IN altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression; altered vascular endothelial growth factor signaling pathway involving the main players; axitinib pharmacodynamics pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6130401C07; fetal liver kinase 1; Flk-1; Flk1; kinase NYK; Krd-1; Ly73; orv; protein-tyrosine kinase receptor flk-1; soluble vascular endothelial growth factor receptor 2; sVEGFR-2; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF receptor-2; VEGFR-2; VEGFR2
Homo sapiens (human) : KDR (kinase insert domain receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kdr (kinase insert domain receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdr (kinase insert domain receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : KDR (kinase insert domain receptor)
Canis lupus familiaris (dog) : KDR (kinase insert domain receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdr (kinase insert domain receptor)
Sus scrofa (pig) : KDR (kinase insert domain receptor)
Chlorocebus sabaeus (African green monkey) : KDR (kinase insert domain receptor)
Heterocephalus glaber (naked mole-rat) : Kdr (kinase insert domain receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl575,932,827 - 75,978,458 (-)Ensembl
GRCm38575,932,827 - 75,979,072 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37576,329,290 - 76,374,453 (-)NCBIGRCm37mm9NCBIm37
MGSCv36576,214,962 - 76,260,125 (-)NCBImm8
Celera573,218,468 - 73,263,674 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Kdr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10836
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.