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Gene: Kdr (kinase insert domain protein receptor) Mus musculus
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Symbol: Kdr
Name: kinase insert domain protein receptor
Description: Exhibits growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of vasculature development. Localizes to several cellular components, including the cell junction; endosome; and external side of plasma membrane. Human ortholog(s) of this gene implicated in artery disease (multiple); macular degeneration (multiple); pancreatic cancer; and urinary bladder cancer. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Orthologous to human KDR (kinase insert domain receptor); PARTICIPATES IN altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression; altered vascular endothelial growth factor signaling pathway involving the main players; axitinib pharmacodynamics pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6130401C07; fetal liver kinase 1; Flk-1; Flk1; kinase NYK; Krd-1; Ly73; orv; protein-tyrosine kinase receptor flk-1; soluble vascular endothelial growth factor receptor 2; sVEGFR-2; vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF receptor-2; VEGFR-2; VEGFR2
Orthologs:
Homo sapiens (human) : KDR (kinase insert domain receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kdr (kinase insert domain receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdr (kinase insert domain receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : KDR (kinase insert domain receptor)
Canis lupus familiaris (dog) : KDR (kinase insert domain receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdr (kinase insert domain receptor)
Sus scrofa (pig) : KDR (kinase insert domain receptor)
Chlorocebus sabaeus (African green monkey) : KDR (kinase insert domain receptor)
Heterocephalus glaber (naked mole-rat) : Kdr (kinase insert domain receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl575,932,827 - 75,978,458 (-)Ensembl
GRCm38575,932,827 - 75,979,072 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37576,329,290 - 76,374,453 (-)NCBIGRCm37mm9NCBIm37
MGSCv36576,214,962 - 76,260,125 (-)NCBImm8
Celera573,218,468 - 73,263,674 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Kdr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10836
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.