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Gene: Lcat (lecithin cholesterol acyltransferase) Mus musculus
Symbol: Lcat
Name: lecithin cholesterol acyltransferase
Description: Exhibits phosphatidylcholine-sterol O-acyltransferase activity. Involved in cholesterol metabolic process; lipoprotein biosynthetic process; and regulation of high-density lipoprotein particle assembly. Localizes to the extracellular space. Used to study Norum disease. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Orthologous to human LCAT (lecithin-cholesterol acyltransferase); PARTICIPATES IN kidney failure pathway; reverse cholesterol transport pathway; glycerophospholipid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI046659; D8Wsu61e; lecithin-cholesterol acyltransferase Lcat; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase
Homo sapiens (human) : LCAT (lecithin-cholesterol acyltransferase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lcat (lecithin cholesterol acyltransferase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lcat (lecithin-cholesterol acyltransferase)
Pan paniscus (bonobo/pygmy chimpanzee) : LCAT (lecithin-cholesterol acyltransferase)
Canis lupus familiaris (dog) : LCAT (lecithin-cholesterol acyltransferase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lcat (lecithin-cholesterol acyltransferase)
Sus scrofa (pig) : LCAT (lecithin-cholesterol acyltransferase)
Chlorocebus sabaeus (African green monkey) : LCAT (lecithin-cholesterol acyltransferase)
Heterocephalus glaber (naked mole-rat) : Lcat (lecithin-cholesterol acyltransferase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl8105,939,551 - 105,943,382 (-)Ensembl
GRCm388105,939,551 - 105,943,402 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378108,463,451 - 108,467,302 (-)NCBIGRCm37mm9NCBIm37
MGSCv368108,828,681 - 108,832,511 (-)NCBImm8
Celera8110,167,599 - 110,171,451 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lcat
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10859
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.